Preparation of 2-Pyridinecarbaldehyde Thiosemicarbazone by Microwave Irradiation

Thiosemicarbanzones have received considerable attention because of their pharmacological activities. They have numerous biological activities, e.g. anticarcinogenic, antibacterial, anti-HIV, anticancer, fungicides, antiviral, antifungal, antitumour, etc[1]. Chandra and co-workers have been reported the synthesis of title compound by the direct reaction 2-pyridine-carbaldehyde and thiosemicarbazide by reflux[2]. A fast and efficient method has been developed for the synthesis of 2-pyridinecarbaldehyde thiosemicarbazone under microwave irradiation. 2-pyridinecarbaldehyde thiosemicarbazone has been synthesized by the reaction of 2-pyridinecarbaldehyde and thiosemicarbazide using microwave irradiation. The preparation of title compound by this way has several advantages including shorter reaction times, cleaner reaction profiles and simple experimental/product isolation procedures[3,4]. Microwave irradiation presents a powerful tool toward organic reactions. This investigation showed that the used method and the results when compared with conventional processes were found to be inexpensive, more friendly and high yielding. This compound has been characterized by FT-IR, ¹H-NMR, ¹³C-NMR techniques and elemental analysis. References 1. Chandra, S.; Kumar, A. Spectrochimica Aceta Part A, 2007, 68, 1410. 2. Chandra, S.; Raizada, S.; Tyagi, M; Sharma, P. K. Spectrochimica Aceta Part A, 2008, 69, 816. 3. Zhang, X-H,; Wang, L-Y,; Zh-X,; Tan, Sh-H,; Zhang, Z-X. dyes and pigments , 2008, 79, 205. 4. Loupy A. Microwaves in organic synthesis. Weinheim: Wiley-VCH; 2002.