Antimicrobial Potential Of Hydroxymethylglutaryl-Coa Reductases Inhibitors

Bacterial resistance to antibiotics represents a serious and worrying public health problem worldwide. Considering this scenario, the reuse of drugs already known is presented as a quick and less expensive opportunity, being considered an attractive alternative for the development of new drugs and treatments, this study proposes the contemplation of an ecumenical scenario on the antimicrobial potential of statins, in this context, its objective is to carry out a narrative review of the scientific literature, providing a basis for future research and new possibilities in the face of this public health problem. Narrative review was used as a method to conceive the state of the art and support a pertinent appreciation of the theme. To initiate the investigation, a guiding question was prepared to conduct the entire research process, using the PICo strategy (Population / Interest / Context). The scientific literature presents studies that reveal the antimicrobial potential of statins against different bacterial strains. The antibacterial activity appears to be a specific statin / specific bacterium, with an emphasis on simvastatin and atorvastatin, and Gram-positive bacteria, particularly S. aureus, as well as rifampicin adjuvant activity in the fight against mycobacteria.