Jackfruit seed powder supplementation attenuates high sugar diet-induced hyperphagia and hyperglycemia in mice

The prevalence of obesity and other metabolic syndromes is rapidly increasing in Bangladesh and other South Asian countries, leading to increased mortality and morbidity due to diabetes and cardiovascular diseases. Intake of high sugar diets is strongly associated with the development of obesity, diabetes, and other metabolic diseases. Diets that are rich in dietary fiber have been reported to have substantial health benefits. The beneficial effects of a fiber-rich diet are prevention of obesity, improved glucose levels, and control of the profile of blood lipids. Jackfruit seed powder (JSP) is a good source of dietary fiber and can be a possible candidate to fight against metabolic diseases. Therefore, we designed this experiment to evaluate the beneficial effects of jackfruit seed powder supplementation on the development of metabolic syndromes. Four diet paradigms such as normal diet (control) and 20% sucrose (HSD) with or without 20% jackfruit seed powder (JSP) were selected and the feeding experiment was continued for a period of 8 weeks. Though Jackfruit seed powder supplementation did not show remarkable changes in the normal diet-fed mice, a significant reduction was observed in high sugar diet-induced hyperphagia. Additionally, the body weight was significantly lower in JSP supplemented group as compared with that of the HSD group. The addition of jackfruit seed powder significantly improved glucose tolerance in the HSD group. Reduction in liver weight was also observed in JSP administered group. However, a significant difference in total cholesterol and triglycerides and a decreasing tendency of LDL- cholesterol in blood was observed due to JSP supplementation. Overall, jackfruit seed powder consumption could play a crucial role in the management of metabolic disorders caused by high sugar diets.