Events The 2nd International Electronic Conference on Catalysis Sciences—A Celebration of Catalysts 10th Anniversary

Event submissions

Published

10.3390/ECCS2021-11038 (registering DOI)

This submission belongs to the session H. Catalysis in Organic and Polymer Chemistry of the event The 2nd International Electronic Conference on Catalysis Sciences—A Celebration of Catalysts 10th Anniversary

Published date

14 Oct, 2021

Academic Editor

Kotohiro Nomura

Citation

Elina Makarova, Alexey Makarov, Lilya Dzhemileva, Usein Dzhemilev, Zr-Catalyzed Cycloalumination of 1,2-Dienes in the Synthesis of Lyngbioic Acid Derivatives., in Proceedings of The 2nd International Electronic Conference on Catalysis Sciences—A Celebration of Catalysts 10th Anniversary, 15 October–30 October 2021, MDPI: Basel, Switzerland, doi: 10.3390/ECCS2021-11038

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Zr-Catalyzed Cycloalumination of 1,2-Dienes in the Synthesis of Lyngbioic Acid Derivatives.

Elina Makarova ¹

Alexey Makarov ¹

Lilya Dzhemileva ¹

Usein Dzhemilev ¹

1. IPC RAS

Abstract

Using at the key stage of the synthesis the reaction of catalytic cycloalumination of 1,2-dienes with Et3Al in the presence of catalytic amounts of Cp2ZrCl2 (Dzhemilev reaction), an original method for the preparation of analogs of natural Lyngbioic acid with high yields and stereoselectivity was developed, which are key synthons in the preparation of derivatives natural Grenadamide.

Keywords

Zr-Catalyzed Cycloalumination

analogs of natural Lyngbioic acid.

Manuscript

MakarovaEKh.pdf

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Ti-catalyzed cross-cyclomagnesiation in the synthesis of natural and synthetic dienoic and trienoic fatty acids exhibiting a wide range of biological activities.