EventsThe 16th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-16-01106
This submission belongs to the session a. General Organic Synthesis of the event The 16th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Oct, 2012
Citation
Thies Thiemann, Bassam al Hindawi, Fraser White, Bernhard Bugenhagen, Farah Barkhad, Mohammed Mubashar Malik Khan, Yosef Al-Jasem, Crystal Structures of Some 2-Alkoxybenzamides, in Proceedings of The 16th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2012, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-16-01106
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Crystal Structures of Some 2-Alkoxybenzamides

Yosef Al-Jasem 1
Mohammed Mubashar Malik Khan 1
Farah Barkhad 1
Bernhard Bugenhagen 2
Fraser White 3
Bassam al Hindawi 4
Thies Thiemann 4
1. Faculty of Engineering, UAE University, Al Ain, Abu, Dhabi, UAE
2. Department of Inorganic Chemistry, University of Hamburg, D-20146 Hamburg, Germany
3. Agilent Technologies UK, Oxford, UK
4. Department of Chemistry, UAE University, Al Ain, Abu Dhabi, UAE
Abstract
o-Alkoxybenzamides are known to have biological activity. Thus, a group of o-methoxybenzamides constitutes dopamine receptor antagonists. Others, such as o-hexyloxybenzamide, have been found to have antifungal activity. In our search for cocrystal formation utilizing benzamides with the aim of improving solubility, stability and bioavailability during application of the molecules, we have first looked at the single crystal X-ray structures of the three o-alkoxybenzamides, o-allyloxybenzamide (1), o-propoxybenzamide (2), and o-pentoxybenzamide (3).
Keywords
o-alkoxybenzamides
O-alkylation
crystal structure
intermolecular bonding networks
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