Events The 16th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 16th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Oct, 2012

Citation

Paulo J. G. Coutinho, M. Sameiro T. Gonçalves, B. Rama Raju, Studies of DNA Interactions with Functionalizedbenzo[a]phenoxazinium Chlorides, in Proceedings of The 16th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2012, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-16-01116

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Studies of DNA Interactions with Functionalizedbenzo[a]phenoxazinium Chlorides

B. Rama Raju ^1,2

M. Sameiro T. Gonçalves ¹

Paulo J. G. Coutinho ¹

1. Centro de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

2. Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

Abstract

A new series of water-soluble benzo[a]phenoxazinium salts mono- or disubstituted with 3-chloropropyl groups at the amine of position 9, and also at the hydroxyl function of position 2, were synthesized. The interaction of these compounds with DNA phosphate was investigated. It was found that the functionalized terminal has a dramatic influence on the type of interaction with the amino group at the 9-position greatly promoting intercalation.

Keywords

Benzo[a]phenoxazines

DNA interactions

intercalation

photophysical studies

Aqueous Synthesis of 2-Amino-tetrahydrobenzo[b]pyrans by a Green, Efficient and Simple Organocatalyst

Synthesis and Photophysics Behaviour in AOT/cyclohexane w/o Microemulsions of a New Benzo[a]phenoxazinium Chloride with 3-((3-chloropropyl)disulfanyl)propyl)Amino Group