EventsMOL2NET'21, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 7th ed.
Event submissions
Published
with-doi10.3390/mol2net-07-11226
This submission belongs to the session 03. NANOBIO.MAT-07: Nanotech., Biomed. Eng., & Mat. Sci. Congress, Birmingham & Portsmouth, UK-Jackson & Fargo, USA, 2021. of the event MOL2NET'21, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 7th ed.
Published date
26 Oct, 2021
Academic Editor
author-avatarHumbert G. Díaz
Citation
Kun Liu, César Martin Plagaro, Bairong Shen, Effects of Serum 25-Hydroxyvitamin D concentration on Insulin Resistance and IVF-ET outcomes in PCOS, in Proceedings of MOL2NET'21, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 7th ed., 25 January–30 December 2021, MDPI: Basel, Switzerland, doi: 10.3390/mol2net-07-11226
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Effects of Serum 25-Hydroxyvitamin D concentration on Insulin Resistance and IVF-ET outcomes in PCOS

Kun Liu 1
César Martin Plagaro 2
Bairong Shen 3
1. The First Hospital of Lanzhou University, Lanzhou, Gansu, China
2. Biochemistry and Molecular Biology Department, University of the Basque Country UPV/EHU
3. Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China
Abstract

Objective To investigate the effects of serum 25-hydroxyvitamin D on insulin resistance and IVF pregnancy outcomes in the patients with PCOS. Methods The patients with PCOS were divided into vitamin D deficiency group and sufficient group according to the concentration of serum vitamin D. To compare and analyze the relationship between 25(OH) D and indicators of insulin resistance and secretion function in patients, and effects on pregnancy outcomes. Results VDD group with significantly higher proportion of high risk of 1h postprandial blood sugar, hyperinsulinemia and insulin resistance, but with significantly lower ISIcomp (P<0.05). G60、 time-glycemic AUC has predictive value on VDD in PCOS. Vitamin D sufficient is in favor of improving the quality of embryos (r=0.3, P=0.014), but does not affect IVF pregnancy outcomes. Conclusion VDD of the patients with PCOS incline to be combined with insulin regulatory dysfunction, but it has no harm to IVF pregnancy outcomes.

Keywords
25-hydroxyvitamin D
insulin resistance
embryo
pregnancy
Manuscript
mol2net-04_054042.pdf
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