Organocatalytic synthesis of N-benzamido-1,4-dihydropyridine derivatives and their effect against different cancer cell lines

Dihydropyridines (DHPs) have a wide presence in nature, which makes them privileged structures with possible chemical and biological properties. They are found as part of the cofactors NADH and NADPH (energy transporters in cellular metabolic reactions) and since these compounds are part of a large number of biological processes, DHPs have become molecules of high interest for attacking these potential therapeutic targets.

In this work we want to show the toxicity results obtained in four different tumor lines: HeLa (cervix), Jurkat (leukemia), A549 (lung) and MIA-PaCa-2 (pancreas), using the racemic 1,4-DHP obtained from different derivatives of alkylidenemalononitrile and hydrazone through an organocatalytic process.

The in vitro cytotoxicity values ​​and the luminescent properties studied encourage us to go one step further in our research and carry out the tests in vivo as well.