Events7th International Electronic Conference on Medicinal Chemistry
Event submissions
Published
with-doi10.3390/ECMC2021-11511
This submission belongs to the session S3. General of the event 7th International Electronic Conference on Medicinal Chemistry
Published date
03 Nov, 2021
Academic Editor
author-avatarJean Jacques Vanden Eynde
Citation
Sanja Matić, Tanja Soldatović, Enisa Selimović, Biljana Šmit, Asija Halilagić, Marijana Vasić, Petar Stanić, In vitro DNA damage protection activity of four novel bridged dinuclear cis- and transplatin-L-Zn(terpy) complexes, in Proceedings of 7th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2021-11511
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In vitro DNA damage protection activity of four novel bridged dinuclear cis- and transplatin-L-Zn(terpy) complexes

image
Tanja Soldatović 1
Sanja Matić 2
Petar Stanić 2
Asija Halilagić 1
Enisa Selimović 1
Marijana Vasić 3
Biljana Šmit 2
1. State University of Novi Pazar, Department of Natural-Mathematical Sciences, Vuka Karadžića 9, 36300 Novi Pazar, Serbia
2. University of Kragujevac, Institute for Information Technologies Kragujevac, Department of Science, Jovana Cvijića bb, 34000 Kragujevac, Serbia
3. Academy of Professional Studies Šumadija, Department in Kruševac, Kosančićeva 36, 37000 Kruševac, Serbia
Abstract

For investigation of in vitro DNA damage protection activity four novel dinucler cis- and transplatin-L-Zn(terpy), where bridging ligand L = pyrazine or 4,4’-bipyridyl, were synthesized. DNA protective effect of the complexes at various concentrations (25, 50, 100, 200 and 400 μg/mL) against the hydroxyl and peroxyl radicals-induced DNA damage were determined using two different in vitro antioxidant assays. Dinuclear complexes exhibited moderate to high DNA-protective effects which depend on the geometry of [PtCl2(NH3)2] complexes as well as the type of the bridging ligand.

Keywords
cisplatin
transplatin
Zn(terpy) complexes
DNA damage
hydroxyl radical
peroxyl radical
Poster
Submission ID sciforum-053488_ Slideshow_ 7th International Electronic Conference on Medicinal Chemistry.pdf
Submission ID sciforum-053488_ Slideshow_ 7th International Electronic Conference on Medicinal Chemistry.pdf
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