Phytochemical evaluation and GC-MS analysis of alkaloid rich fraction of Millettia aboensis leaves

ABSTRACT

Millettia aboensis is a medicinal plant that has been reported to possess several pharmacological properties such as anti-inflammatory, anti-oxidant and anti-microbial activities with no evidence of anti-fertility properties. This present study was designed to investigate the phytocompounds present in alkaloid rich fraction of the of M. aboensis leaf in order to ascertain how these bioactive compounds contribute to the anti-implantation and abortifacient activities. The phytochemical result showed abundance of alkaloids, while terpenoids, flavonoids were present in moderate amount. Reducing sugar, steroids and glycosides were sparingly present. The GC-MS analysis of the alkaloid rich fraction revealed the presence of 2,4(1H,3H)-pyrimidinedione, 1,3,5-trimethyl, 6-cyanoquinoline, pyrimidine, 2-amino-6-phenyl, 3-quinolinecarbonitrile, 3-isothiazolecarboxamide1, 3-dimethyl-4-amino-4,5(1H)-dihydro-1,2,4-triazole-5-one, 3-demethyl-3-ethylthiocolchicine. The phytochemical and GC-MS evaluations of alkaloid rich fraction of M. aboensis leaf revealed the presence of important bioactive compounds with pharmacological and medicinal properties. Hence, the presence of these phytoconstituents could be responsible for the abortifacient and anti-implantation of the plant.