EventsThe 25th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-25-11629
This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 25th International Electronic Conference on Synthetic Organic Chemistry
Published date
12 Nov, 2021
Academic Editor
author-avatarJulio A. Seijas
Citation
Alexey Makarov, Elina Makarova, Lilya Dzhemileva, Usein Dzhemilev, An original method for the synthesis of partially deuterated natural lembehyne B and the study of its biological activity., in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11629
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An original method for the synthesis of partially deuterated natural lembehyne B and the study of its biological activity.

Alexey Makarov 1
Elina Makarova 1
Lilya Dzhemileva 1
Usein Dzhemilev 1
1. IPC RAS
Abstract

An efficient method for the synthesis of a partially deuterated analogue of the natural neuritogenic alkynol, lembehyne B, has been developed for the first time, based on the use of a new reaction of Ti-catalyzed cross-cyclomagnesiation of O-containing 1,2-dienes and terminal aliphatic 1,2-dienes using EtMgBr in high yield. The introduction of two deuterium atoms is carried out at the stage of treatment of the formed in situ magnesacyclopentane with D2O.

Keywords
Ti-catalyzed cross-cyclomagnesiation
lembehyne B
magnesacyclopentane.
Manuscript
sciforum_048080_original_MakarovAA1-done.pdf
DESIGN, SYNTHESIS AND STUDIES OF NOVEL IMIDAZOLES
An original method for the synthesis and the study of its biological activity of natural lembehyne B aromatic analogs.