EventsThe 25th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-25-11630
This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 25th International Electronic Conference on Synthetic Organic Chemistry
Published date
12 Nov, 2021
Academic Editor
author-avatarJulio A. Seijas
Citation
Alexey Makarov, Elina Makarova, Lilya Dzhemileva, Usein Dzhemilev, An original method for the synthesis and the study of its biological activity of natural lembehyne B aromatic analogs., in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11630
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An original method for the synthesis and the study of its biological activity of natural lembehyne B aromatic analogs.

Alexey Makarov 1
Elina Makarova 1
Lilya Dzhemileva 1
Usein Dzhemilev 1
1. IPC RAS
Abstract

In the development of earlier initiated studies on the synthesis of natural and synthetic neuritogenic alkynols, lembehynes A-C, which, simultaneously, exhibit high antitumor activity, we have developed a method for the synthesis of an analogue of natural lembehyne B containing a phenyl radical in its structure. It has been shown that the synthesized aromatic analogue of lembehyne B exhibits higher antitumor activity in vitro to a number of tumor cell lines (Jurkat, K562 and U937).

Keywords
Antitumor activity
aromatic analogue of lembehyne B.
Manuscript
sciforum_048085_original_MakarovAA2-done.pdf
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