Natural and synthetic dienoic and trienoic acids - an original method for the synthesis and antitumor activity.

The report contains the recent data about our research on the synthesis and study of the properties of unique natural and synthetic Z,Z-dienoic and Z,Z,Z-trienoic fatty acids exhibiting a wide range of biological activities (antiviral, antibacterial, neuritogenic, antitumor, antiparasitic, fungicidal). All the methods and approaches for the synthesis of the above-mentioned unsaturated carboxylic acids presented in the report are based on the using at the key stage of the synthesis of the catalytic cross-cyclomagnesiation of 1,2-dienes developed by the main co-authors.