EventsThe 25th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-25-11649
This submission belongs to the session S1. General Organic Synthesis of the event The 25th International Electronic Conference on Synthetic Organic Chemistry
Published date
13 Nov, 2021
Academic Editor
author-avatarJulio A. Seijas
Citation
Arslan Akhmetov, Zarema Sadretdinova, Lilya Dzhemileva, Airat Tuktarov, Usein Dzhemilev, Covalent binding of C₆₀ fullerene to quadricyclans: a synthetic avenue to hexamethanofullerenes with promising antitumor activity, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11649
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Covalent binding of C60 fullerene to quadricyclans: a synthetic avenue to hexamethanofullerenes with promising antitumor activity

Arslan Akhmetov 1
Zarema Sadretdinova 2
image
Lilya Dzhemileva 2
Airat Tuktarov 2
Usein Dzhemilev 2
1. 450075 Institute of petrochemistry and catalysis of RAS Pr. Oktyabrya 141, Ufa, Russia
2. 450075 Institute of petrochemistry and catalysis of RAS Pr. Oktyabrya 141, Ufa, Russia
Abstract

Using the Bingel-Hirsch reaction, two new hexamethanofullerenes containing six quadricyclane fragments have been synthesized. Preliminary experiments have established that the synthesized compounds have a high antitumor effect in combination with cis-platinum on human T-lymphoblastic leukemia cells (Jurkat cells).

Keywords
[60]fullerene
quadricyclane
Bingel-Hirsh reaction
hexamethanofullerene
cytotoxic
antitumor activity
Manuscript
sciforum_049947_original_Akhmetov-done.pdf
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