Events The 25th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 25th International Electronic Conference on Synthetic Organic Chemistry

Published date

13 Nov, 2021

Academic Editor

Julio A. Seijas

Citation

Zarema Sadretdinova, Arslan Akhmetov, Lilya Dzhemileva, Vladimir D'yakonov, Airat Tuktarov, Usein Dzhemilev, Fullerenyl-1,2,3-triazoles: synthesis and cytotoxic activity, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11659

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Fullerenyl-1,2,3-triazoles: synthesis and cytotoxic activity

Zarema Sadretdinova ¹

Arslan Akhmetov ¹

Lilya Dzhemileva ¹

Vladimir D'yakonov ¹

Airat Tuktarov ¹

Usein Dzhemilev ¹

1. Institute of Petrochemistry and Catalysis of RAS, Ufa 450075, Russia

Abstract

For the first time, the reaction of fullerenyl azide with terminal acetylenes has been used to synthesize previously undescribed 1-butyl-2-triazolylfullerenes, in which the heterocyclic fragment is directly attached to the fullerene backbone. Water-soluble complexes of the synthesized adducts of fullerene with polyvinylpyrrolidone showed high cytotoxic activity towards tumor cells of the Jurkat, K562, U937 lines.

Keywords

fullerene

triazolylfullerenes

cytotoxic activity

tumor cells of the Jurkat

K562

U937 lines.

Manuscript

sciforum_050136_original_SadretdinovaZR-DONE.pdf

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