EventsThe 25th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-25-11676
This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 25th International Electronic Conference on Synthetic Organic Chemistry
Published date
13 Nov, 2021
Academic Editor
author-avatarJulio A. Seijas
Citation
Didier Villemin, Florian Faucher, Nathalie Bar, Zahira Kibou, Noureddine Choukchou-Braham, An Easy and Simple Synthesis of Ricinine and its Analogues, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11676
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An Easy and Simple Synthesis of Ricinine and its Analogues

Florian Faucher 1
Didier Villemin 2
Nathalie Bar 3
Zahira Kibou 4
Noureddine Choukchou-Braham 4
1. Feluy research center, 7181 Feluy, Belgique
2. Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN et Université de Caen Normandie, 14050 Caen, France, France
3. Laboratoire de Chimie Moléculaire et Thioorganique, UMR CNRS 6507, INC3M, FR 3038, ENSICAEN et Université de Caen Normandie, 14050 Caen, France
4. Laboratoire de Catalyse Et Synthèse en Chimie Organique, Faculté des Sciences, Université de Tlemcen, BP 119, 13000, Tlemcen, Algeria
Abstract

Ricinine is an alkaloide of Ricinus commununis posseding numerous biological properties.

Ricinidine (1-Methyl-2-oxo-1,2-dihydro-3-pyridinecarbonitrile) and new N-analogues of Ricinidine were obtained by the reaction of ethyl α-ethoxyethylidenecyanoacetate with amines. The ethyl α-ethoxyethylidenecyanoacetate was prepared from ethyl cyanoacetate. Biologically amines as tryptamine and histamine were used in order to introduced a second pharmacophore.

Keywords
ricinine
alkaloid synthesis
cyclo-condensation
biological active amines
Manuscript
sciforum_053634.pdf
Oral Presentation
Ricinidine.pptx
Poster
cRicinine.pdf
cRicinine.pdf
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