Efficient Synthesis of Multi-Component Spirooxindoles Using Fe₃O₄@SiO₂@Pr-Tris(aminomethyl)amine: as Green Organocatalyst Reusable in Aqueous Environment

Green chemistry as a powerful tool plays momentous role in various research fields such as synthetic organic, biomedical, industrial chemistry, In summary, an efficacious method is described for the synthesis of spirooxindole derivatives using Fe₃O₄@SiO₂@Pr-Tris(aminomethyl)amine a green catalyst. This is a one-pot three-component condensation in water as a clean and environmentally favorable media. The present procedure proposes various remarkable privileges such as mild reaction conditions, simple work-up procedure and environment friendly. Moreover, the catalyst used is easily recovered by the external magnetic field and reused without significant deterioration in catalytic activity after at least five times.