EventsThe 25th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-25-11684
This submission belongs to the session S4. Polymer and Supramolecular Chemistry of the event The 25th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2021
Academic Editor
author-avatarJulio A. Seijas
Citation
Ramon J Estevez, maria campos, Victor M Sánchez-Pedregal, Pablo López-Carracedo, Juan C Estévez, Synthesis and Structural Study of a New b-Turn Inducer Peptidomimetic Incorporating 1-Amino-1-aminomethylcyclohexane, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11684
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Synthesis and Structural Study of a New b-Turn Inducer Peptidomimetic Incorporating 1-Amino-1-aminomethylcyclohexane

maria campos 1
Victor M Sánchez-Pedregal 2
Pablo López-Carracedo 1
image
Ramon J Estevez 3
Juan C Estévez 1
1. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
2. Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
3. Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares and Departamento de Química Orgánica, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain., Seychelles
Abstract

The search for structures that fold in the form of peptide turns, in which α-amino acids are totally or partially replaced by constraints made up of β- or γ-amino acids is of great interest. But so are those structures in which α-amino acids are amino acids are replaced by non-amino acid molecules, which also give rise to peptide turns. The interest, in both cases, is due to the limitations of the α-peptides, mainly its low structural diversity, due to the limited number of proteinogenic acids as well as its remarkable conformational flexibility and low metabolic stability.

This communication deals with the turn inducer properties of peptidomimetic I. Its synthesis and structural study will be discussed.

Keywords
amino acids
peptides
1,2-diamines
supramolecular chemistry
Manuscript
sciforum_052317.pdf
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