New synthesis of imidazo [1,2-a] pyrimidine catalyzed by gold nanoparticles

Heterocyclic compounds are abundant in natural products, bioactive compounds and play a huge role in the present repertoire of medicinal chemists due to their potential capability to modulate physicochemical properties. As a result, chemists have focused their efforts on the functionalization of heterocycles. Nitrogen-containing fused heterocyclic compounds are important organic molecules. They're found in a variety of natural products, medicinal compounds, and functional materials as structural fragments. The imidazo[1,2-a]pyrimidine skeleton is one of them, and it's linked to the pharmacological activity of related drugs. Anticancer activity medicines, anxiolytic drugs, and anti-inflammatory activity pharmaceuticals all have this structural pattern. Many of them have biological properties, such as antifungal, antimicrobial, antiviral, and anxiolytic properties, which are used in medications like divaplon and fasiplon.

The invention of a new approach to manufacture 2- arylsubstituted imidazo[1,2-a]pyrimidines efficiently piqued our interest, given the powerful bioactivities of molecules with an imidazopyrimidine core. As a result, appropriate methods for manufacturing such molecules remain appealing. In this context, we'd like to present a feasible green chemistry approach for the synthesis of 2-phenyl-imidazo [1,2-a] pyrimidines.