EventsThe 25th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-25-11720
This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 25th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2021
Academic Editor
author-avatarJulio A. Seijas
Citation
Nilesh Shantaram Pawar, Pramod Nagraj Patil, Rajashri N. Pachpande, An efficient synthesis and antibacterial activity of some novel 3,4–Dihydropyrimidin-2-(1H)-ones, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11720
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An efficient synthesis and antibacterial activity of some novel 3,4–Dihydropyrimidin-2-(1H)-ones

Nilesh Shantaram Pawar 1
Pramod Nagraj Patil 2
Rajashri N. Pachpande 3
1. Department of Chemistry, Pratap College, Amalner 425401, India
2. Department of Applied Science and Humanities, R. C. Patel Institute of Technology, Shirpur 425405, India
3. DNCVPS, Shirish Madhukarrao Chaudhari College, Jalgaon Tal. and Dist. Jalgaon- 425 001
Abstract

We have efficiently synthesized mono as well as bis and also spirocyclic products of 3,4-dihydropyrimidin-2(1H)-ones (DHPMs) by refluxing a reaction mixture of the three components in Deep Eutectic Solvent (DES) to generating “libraries from libraries”. Synthesized spirofused heterotricyclic compounds containing urea moiety is potent against bacteria. Overall antibacterial study, from the synthesised compounds. Some of 3, 4–dihydropyrimidin-2-(1H)-ones compounds were found to possess anti-bacterial efficacy.

Keywords
3,4-dihydropyrimidin-2(1H)-ones
bis-dihydropyrimidinones
spirofused hetrotricyclic
Deep Eutetic Solvent and Antibacterial activity.
Manuscript
sciforum_051294-done.pdf
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