EventsThe 25th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-25-11724 (registering DOI)
This submission belongs to the session S1. General Organic Synthesis of the event The 25th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2021
Academic Editor
author-avatarJulio A. Seijas
Citation
Maamar HAFFAS, Naima BENKIKI, Ramzi MAADADI, Oualid TALHI, Chafai BOUKENTOUCHA, Farid CHEBROUK, Zahia KABOUCHE, In situ one pot hemi-synthesis of new 2-pyridone derivatives, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11724
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In situ one pot hemi-synthesis of new 2-pyridone derivatives

Maamar HAFFAS 1,2,3
Naima BENKIKI 1
Ramzi MAADADI 2,3
Oualid TALHI 3
Chafai BOUKENTOUCHA 4
Farid CHEBROUK 3
Zahia KABOUCHE 2
1. Laboratoire de Recherche Biotechnologie des Molécules Bioactives et de la Physiopathologie Cellulaire, faculté des sciences de la na-ture et de la vie de l’université de BATNA 2 Algérie
2. Université des frères Mentouri-Constantine, Département de chimie, Laboratoire d'Obtention des Substances Thérapeutiques (LOST), Campus Chaabet-Ersas, 25000 Constantine, Algérie
3. Centre de Recherche Scientifique et Technique en Analyses Physico – Chimiques, BP 384, Zone Industrielle Bou-Ismail RP 42004 Bou Ismaïl, Tipaza Algerie
4. Université des Frères Mentouri Constantine 1, Unité de Recherche de Chimie de l’Environnement et Moléculaire Structurale CHEMS, 25000 Constantine, Algerie
Abstract

New 2-pyridone derivatives were hemi-synthetised in situ using essential oils of endemic Algerian plants; Ammodaucus Leucotrichus and eucalyptus citriodora as source of chiral aldehydes (perillaldehyde and citronellal respectively). The one pot reaction was carried out in Ethanol including cyanoacetohydrazide, essential oil, and malononitrile.The reaction mixture was catalysed by potassium carbonate. In the present work; two new compounds of highly functionalized 2-pyridones were obtained as privileged medicinal scaffolds.The structures of 2-pyridone derivatives were confirmed by NMR1H, 13C and 2D.

Keywords
one pot
Essential oil
2-pyridone
Hemi-Synthesis
NMR analysis.
Manuscript
sciforum_051429-done.pdf
Oral Presentation
Poster Maamar HAFFAS.pptx
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