EventsThe 25th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-25-11730
This submission belongs to the session S1. General Organic Synthesis of the event The 25th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2021
Academic Editor
author-avatarJulio A. Seijas
Citation
Paula Munín-Cruz, Marcos Rúa-Sueiro, Juan Manuel Ortigueira, Mª Teresa Pereira, José Manuel Vila, Study on the effect of the ligand structure in palladium organometallic catalysts in the Suzuki˗Miyaura cross˗coupling reaction, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11730
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Study on the effect of the ligand structure in palladium organometallic catalysts in the Suzuki˗Miyaura cross˗coupling reaction

Paula Munín-Cruz 1
Marcos Rúa-Sueiro 2
Juan Manuel Ortigueira 2
Mª Teresa Pereira 2
José Manuel Vila 2
1. Department of Inorganic Chemistry, University of Santiago de Compostela, Spain
2. Department of Inorganic Chemistry, University of Santiago de Compostela
Abstract

In this communication we present the results obtained using a family of cyclometallated palladium compounds as catalysts for the Suzuki-Miyaura cross-coupling reaction between an aryl halide and phenylboronic acid.

We have studied the structural factors that enhance the catalysts efficiency for this process through the synthesis of a library of analogous compounds containing thiosemicarbazone ligands with substituted rings and ferrocene diphosphine (dppf). We found that the best conversion rates are obtained with ligands bearing methoxy-disubstituted aromatic rings; and that the process performance is improved when R2 is a methyl group bound to the thioamidic nitrogen.

These results lay the foundations for the design and development of novel and more efficient palladium catalysts based in thiosemicarbazones.

Keywords
Organometallic chemistry
Cyclometallation
Catalysis
Suzuki-Miyaura reaction
Cross-coupling
Manuscript
sciforum_051549-done.pdf
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