Events The 25th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-25-11736 (registering DOI)

This submission belongs to the session S1. General Organic Synthesis of the event The 25th International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2021

Academic Editor

György Keglevich

Citation

Nikolay Pakholka, S. G. Krivokolysko, Viktor Dotsenko, Viktor Abramenko, Synthesis and Structure of (2E)-3-Aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11736

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Synthesis and Structure of (2E)-3-Aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles

Nikolay Pakholka ¹

S. G. Krivokolysko ¹

Viktor Dotsenko ²

Viktor Abramenko ¹

1. Laboratory KhimEx, V. Dal Lugansk State University, Lugansk

2. Kuban State University, Krasnodar, 350040 Russia North Caucasus Federal University, Stavropol, 355009 Russia

Abstract

Bromination of (2E)-3-aryl(hetaryl)-2-[4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles proceeds regioselectively at the C5 atom of the thiazole ring with the formation of new (2E)-3-aryl(hetaryl)-2-[5-bromo-4-aryl(hetaryl)-1,3-thiazol-2-yl]acrylonitriles. The latter were alternatively obtained by the reaction of aldehydes,cyanothioacetamide, α-bromoketones and bromine in the presence of triethylamine in DMF. Structure of the keycompounds was confirmed using 2D NMR spectroscopy and single crystal X-ray diffraction analysis.

Keywords

1,3-thiazoles

5-bromo-1,3-thiazoles

cyanothioacetamide

2-cyanothioacrylamides

bromination

Manuscript

sciforum_051592_done.pdf

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