Events The 25th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 25th International Electronic Conference on Synthetic Organic Chemistry

Published date

15 Nov, 2021

Academic Editor

Julio A. Seijas

Citation

Ilgiz Islamov, Adelya Yusupova, Lilya Dzhemileva, Usein Dzhemilev, Stereoselective synthesis and cytotoxic activity of aromatic polyether macrodiolides containing 1Z,5Z-diene moiety, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11763

Facebook

Twitter

Stereoselective synthesis and cytotoxic activity of aromatic polyether macrodiolides containing 1Z,5Z-diene moiety

Ilgiz Islamov ¹

Adelya Yusupova ¹

Lilya Dzhemileva ¹

Usein Dzhemilev ¹

1. Institute of Petrochemistry and Catalysis, Russian Academy of Sciences

Abstract

The synthesis of previously undescribed aromatic polyether macrodiolides, containing a 1Z,5Z-diene moiety was carried out in 56-72% yields and with >98% stereoselectivity. It has been shown that the synthesized macrodiolides exhibits higher cytotoxic activity in vitro to a number of tumor cell lines (Jurkat, K562 and U937).

Keywords

1,5-Dienoic compounds

Crown Ethers

Cyclomagnesiation

Macrodiolides

Cytotoxicity

Manuscript

sciforum_051709.pdf

Synthesis and characterization of amine functionalized thiosemicarbazone cyclopalladated compounds.

Synthesis and biological evaluation of some substituted benzimidazole derivatives