EventsThe 25th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-25-11772 (registering DOI)
This submission belongs to the session S2. Bioorganic, Medicinal and Natural Products Chemistry of the event The 25th International Electronic Conference on Synthetic Organic Chemistry
Published date
14 Nov, 2021
Academic Editor
author-avatarJulio A. Seijas
Citation
Mohammad G. Dekamin, Hamidreza FaniMoghadam, Para-Aminobenzoic acid-functionalized silica-coated magnetic nanoparticles: a highly efficient and synergistic organocatalyst for on-water synthesis of 2,3-dihydroquinazolin-4(1H)-ones, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11772
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Para-Aminobenzoic acid-functionalized silica-coated magnetic nanoparticles: a highly efficient and synergistic organocatalyst for on-water synthesis of 2,3-dihydroquinazolin-4(1H)-ones

image
Hamidreza FaniMoghadam 1
Mohammad G. Dekamin 2
1. Pharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran
2. Pharmaceutical and Heterocyclic Compounds Research Laboratory, Department of Chemistry, Iran University of Science and Technology, Tehran, 16846-13114, Iran, Hong Kong
Abstract

New para-aminobenzoic acid (PABA) grafted on silica-coated magnetic nanoparticles (Fe3O4@SiO2@Pr-PABA) were prepared. The efficiency of the new Fe3O4@SiO2@Pr-PABA nanoparticles, as a heterogenous nanocatalyst, was examined in the synthesis of biologically-active 2,3-disubstituted-2,3-dihydroquinazolin-4(1H)-one derivatives via one-pot three-component condensation of isatoic anhydride, aromatic aldehydes and aromatic amine on water under reflux conditions. The advantages of this green protocol are low catalyst loading, high to quantitative yields of the favorable products, short reaction times and easy separation and recycle of catalyst.

Keywords
Para-Aminobenzoic acid-functionalized silica-coated magnetic nanoparticles
Supported organocatalyst
On-Water synthesis
2,3-Dihydroquinazolin-4(1H)-ones.
Manuscript
sciforum_052846.pdf
Poster
on-water synthesis of 2,3-dihydroquinazolin .pdf
on-water synthesis of 2,3-dihydroquinazolin .pdf
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