An Efficient Synthesis of Novel Hydrazine-Carboxamides In Water-Ethanol Solvent System as anticancer agents.

Hydrazine-carboxamide has shown a promising anticancer activity. A series of novel Hydrazine-carboxamide derivatives were synthesised in three step process, in first step substituted phenyl urea was synthesised, followed by synthesis of substituted phenyl semicarbazide, finally the substituted phenyl semicarbazide and substituted aromatic aldehydes/ketones were condensed using water-ethanol (2:1) solvent system to obtain final novel series of Hydrazine-carboxamides. The method reported is efficient as it is less time consuming with good yields. Overall anticancer activity, with the synthesised compounds was carried out. Some Hydrazine-carboxamides compounds were found to possess significant anticancer efficacy.