Events The 25th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-25-11794 (registering DOI)

This submission belongs to the session S3. Microwave Assisted Synthesis of the event The 25th International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2021

Academic Editor

Julio A. Seijas

Citation

Nguyen Dinh Thanh, Do Son Hai, Hoang Thi Kim Van, Nguyen Thi Kim Giang, Vu Ngoc Toan, Click reaction of 3-propargyl-4H-pyrano[2,3-d]pyrimidines and peracetylated D-glucopyaranosyl azide under microwave-assisted conditions, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11794

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Click reaction of 3-propargyl-4H-pyrano[2,3-d]pyrimidines and peracetylated D-glucopyaranosyl azide under microwave-assisted conditions

Nguyen Dinh Thanh ¹

Do Son Hai ²

Hoang Thi Kim Van ³

Nguyen Thi Kim Giang ⁴

Vu Ngoc Toan ^5,6

1. Faculty of Chemistry, VNU Hanoi University of Science, 19 Le Thanh Tong, Hanoi (Vietnam)

2. Institute of Technique in Chemistry, Biology and Security Documents (Ministry of Public Security, Vietnam)

3. Viet Tri University of Industry (Phu Tho, Vietnam)

4. Institute of Science and Technology, Ministry of Public Security of Vietnam, 47 Pham Van Dong, Cau Giay, Ha Noi, Vietnam

5. Institute for New Technology (Vietnam Academy of Military Science and Technology), 17 Hoang Sam, Cau Giay, Ha Noi, Viet Nam

6. Faculty of Chemistry, VNU University of Science (Vietnam National University, Hanoi), 19 Le Thanh Ton, Hoan Kiem, Ha Noi, Viet Nam

Abstract

Some D-glucose-conjugated 1H-1,2,3-triazoles having 4H-pyrano[2,3-d]pyrimidines had been synthesized. Click chemistry between N-propargyl-4H-pyrano[2,3-d]pyrimidines and peracetylated d-glucopyaranosyl azide was performed using CuI@Montmorillonite as a catalyst under microwave-assisted conditions. Gram-positive antibacterial activity of these 1H-1,2,3-triazoles was probed using minimum inhibitory concentration. These compounds have screened their antibacterial activity. The detailed structure-activity relationship (SAR) in vitro and in silico studies were performed.

Keywords

D-glucose

1H-1,2,3-triazoles

4H-pyrano[2,3-d]pyrimidines

microwave-assisted

propargyl derivatives.

Manuscript

Click reaction of 3-propargyl-4H-pyrano[2,3-d]pyrimidines.pdf

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