Copper Grafted on Silica-Coated Magnetic Nanoparticles A Highly Efficient and Synergistic Organocatalyst: A sustainable and eco-friendly Reusable Catalyst for Click Reaction.

In this research Cu(II) complex supported on Fe₃O₄@SiO₂@Pr-AIPA core–shell magnetic nanoparticles core–shell magnetic nanoparticles (MNPs) was prepared and applied for synthesis of 1,2,3-Triazole by click reaction. This compounds are one of the most important classes of N-heterocyclic compounds, have applications in pharmaceutical chemistry. Fe₃O₄@SiO₂@Pr-AIPA-Cu MNPs efficiently catalyzed a click reaction between alkyl halides, Sodium Azide, and Alkynes to synthesize corresponding products in high to excellent yields. Among heterogeneous catalysts, MNPs have seen much attention due to high surface-to-volume ratio and their easy separation. The catalyst was recovered using an external magnetic field, and recycled for subsequent reactions without substantial loss of efficiency. The catalyst was recovered using an external magnetic field, and recycled for subsequent reactions without substantial loss of efficiency.