Events The 25th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

10.3390/ecsoc-25-11800 (registering DOI)

This submission belongs to the session S1. General Organic Synthesis of the event The 25th International Electronic Conference on Synthetic Organic Chemistry

Published date

14 Nov, 2021

Academic Editor

Julio A. Seijas

Citation

Victor V Dotsenko, Alena A. Russkih, Nicolai A. Aksenov, Inna Aksenova, Synthesis of new highly functionalized nicotinic acids, in Proceedings of The 25th International Electronic Conference on Synthetic Organic Chemistry, 15 November–30 November 2021, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-25-11800

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Synthesis of new highly functionalized nicotinic acids

Alena A. Russkih ¹

Victor V Dotsenko ^2,3,4

Nicolai A. Aksenov ⁴

Inna Aksenova ⁴

1. Kuban State University

2. Department of Organic Chemistry and Technologies, Kuban State University, 149 Stavropolskaya Str., 350040 Krasnodar, Russia

3. ChemEx Lab, Vladimir Dal’ Lugansk National University

4. North Caucasus Federal University

Abstract

2,2-Dimethyl-5-((phenylamino)methylene)-1,3-dioxane-4,6-dione, prepared by ternary condensation of Meldrum’s acid with triethyl orthoformate and aniline, reacts with cyanoacetic acid hydrazide in the presence of KOH to give 1-amino-5-cyano-2-oxo-1,2-dihydropyridine-3-carboxylic acid, which is useful as drug precursors or perspective ligands.

Keywords

enamino-1,3-dicarbonyls

cyanoacethydrazide

nicotinic acid

Manuscript

sciforum_051774.pdf

Synthesis of N-(hydroxymethylene)thioamides by N- hydroxymethylation of 2-cyanothioacrylamides

Synthesis of kinase inhibitors utilizing thiophile-free Eschenmoser reaction of bromoindol-2-ones and thioamides