Events The 12th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 12th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2008

Citation

Tarek A. Salama, Saad S. Elmorsya, Mohamed A. Ismaila, Tetrachlorosilane-A Versatile Reagent in Organic Synthesis, in Proceedings of The 12th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2008, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-12-01199

Facebook

Twitter

Tetrachlorosilane-A Versatile Reagent in Organic Synthesis

Tarek A. Salama ^1,2

Saad S. Elmorsya ¹

Mohamed A. Ismaila ¹

1. Chemistry Department, Faculty of Science, Mansoura University, 35516-Mansoura, Egypt

2. Chemistry Department, Faculty of Education, Amran University, Amran, Yemen

Abstract

A recent increased attention is witnessed to the use of tetrachlorosilane (TCS), a cheap industrial intermediate, as a versatile reagent in organic synthesis. For example, TCS was used as an effective dehydrating agent, trans-silylating reagent and as a starting substrate for in situ preparation of other useful stoichiometric reagents in synthetic organic chemistry. Of these reagents TCS-NaI (Iodotrichlorosilane, ITCS), TCS-NaN3 (azidochlorosilanes) and TCS in combination with ZnCl2, Zn, KCN, Na2S and others. Some selected synthetic applications of TCS as dehydrating agent as well as one of its based "in situ" reagents (TCS-NaN3) are briefly highlighted herein.

Keywords

n/a

Solvent-mediated reactivity of b-aminoalcohols against dialkyloxalate: synthesis of tetrasubstituted oxalamide and/ or morpholin-2,3-dione derivatives.

Synthesis of Enantiopure Methyl (1S,2S,3R,4S,5R)-2-Amino-3,4,5-trihydroxycyclopentanecarboxylate