Events The 12th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 12th International Electronic Conference on Synthetic Organic Chemistry

Published date

25 Nov, 2008

Citation

Elliot Coulbeck, Jason Eames, Parallel Kinetic Resolution of 1-Phenylethanol Using Quasi-Enantiomeric Active Esters, in Proceedings of The 12th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2008, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-12-01208

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Parallel Kinetic Resolution of 1-Phenylethanol Using Quasi-Enantiomeric Active Esters

Elliot Coulbeck ¹

Jason Eames ¹

1. Department of Chemistry, The University of Hull, Cottingham Road, Kingston upon Hull, UK HU6 7RX

Abstract

Parallel Kinetic Resolutions (PKRs) involves the parallel separation of enantiomers under kinetic control. We have recently reported the parallel kinetic resolution of racemic oxazolidinone (rac)-4 using a combination of quasienantiomeric active esters (S)-5 and (R)-6. These processes proceeded efficiently to give separable diastereoisomeric adducts (S,R)-syn-7 and (R,S)-syn-8 in good yields with excellent levels of stereocontrol (>90% d.e.).

Keywords

n/a

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