EventsThe 12th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-12-01228
This submission belongs to the session a. General Organic Synthesis of the event The 12th International Electronic Conference on Synthetic Organic Chemistry
Published date
08 Nov, 2008
Citation
S. M. El Rayes, Convenient synthesis of some methyl-N-[2-(6-oxo-3-p-tolyl-5,6-dihydro-4H-pyridazin-1-yl)-acetamide]alkanoates, in Proceedings of The 12th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2008, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-12-01228
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Convenient synthesis of some methyl-N-[2-(6-oxo-3-p-tolyl-5,6-dihydro-4H-pyridazin-1-yl)-acetamide]alkanoates

S. M. El Rayes 1
1. Department of Chemistry, Faculty of Science, Suez Canal University, Ismailia, Egypt
Abstract
An efficient one-pot synthesis of methyl-N-[2-(6-oxo-3-p-tolyl-5,6-dihydro-4Hpyridazin-1-yl)-acetamide]alkanoates 5a-j and dipeptides 8a-f was successfully realized starting from amino acid esters 4 and azides 3, 7, respectively. The hydrazide 6a was further reacted with selected aldehydes to give the corresponding hydrazones 9a-c.
Keywords
amino acids
dipeptide
azide coupling
dihydro-2H-pyridazin-3-one
hydrazones
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