Cytokinins from plant to human

The plant hormones cytokinins; play a major role in cell division and cell differentiation and affect organogenesis in plant cell cultures and contribute in many other physiological and developmental processes in plants . 60 years ago, was the first discovery of kinetin, the first known member of cytokinines. In market, kinetin is formulated as cosmetic anti-againg topical preparations, without defined dose or mechanism of actions, and till now no systemic formulations with specific dose and mechanism were produced. Some studies reported the effect of kinetin on different human diseases , such as its ability to prevent age-related changes in human skin by protecting the DNA in skin cells from damage (antioxidant effects) and decreasing skin water loss and its therapeutic potential in treatment of the human splicing disease familial dysautonomia in vitro. Our research with kinetin started from studying of its activity in the plants , followed by first screening for the systemic activity of kinetin in mammalian cells at the level of the in vitro study, where we showed for the first time that kinetin exerts anticytotoxic, antioxidant, antigenotoxic and antiapoptotic activities in different cell lines from different origins. The promising in vitro results transferred us to the in vivo stage of the investigations, where we examined the safety of the kinetin for the systemic administration in rats .