Events The 12th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 12th International Electronic Conference on Synthetic Organic Chemistry

Published date

27 Nov, 2008

Citation

Martin Doležal, Katarína Lešnanská, Matúš Peško, Josef Jampílek, Katarína Králová, Pyrazinecarboxamides, Their Synthesis and Evaluation as Potential Herbicides, in Proceedings of The 12th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2008, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-12-01240

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Pyrazinecarboxamides, Their Synthesis and Evaluation as Potential Herbicides

Martin Doležal ¹

Katarína Lešnanská ¹

Matúš Peško ²

Josef Jampílek ³

Katarína Králová ²

1. Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Králové, Charles University in Prague, Heyrovského 1203, 500 05 Hradec Králové, Czech Republic

2. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynská Dolin CH-2, 842 15 Bratislava, Slovak Republic

3. Zentiva a. s., U kabelovny 130, 102 37 Prague 10, Czech Republic

Abstract

The condensation of substituted pyrazinecarboxylic acid chlorides with ring substituted anilines yielded nine substituted pyrazinecarboxylic acid amides. The photo-synthesis inhibition activity of a series of pyrazine derivatives was investigated. The synthesis, analytical and biological data of the newly synthesized compounds are presented in this paper. The most active inhibitor of the oxygen evolution rate in spinach chloroplasts was 2-(5-methyl-pyrazine-2-carboxamido)benzoic acid (9, IC50 = 85.0 µmol·L-1).

Keywords

synthesis of pyrazinecarboxamides

photosynthesis inhibiting activity

lipophilicity

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Synthesis of Esters of Substituted 6-Aminohexanoic Acid as Potential Transdermal Penetration Enhancers