EventsThe 12th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-12-01241
This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 12th International Electronic Conference on Synthetic Organic Chemistry
Published date
26 Nov, 2008
Citation
Katerina Brychtova, Oldrich Farsa, Jozef Csollei, Synthesis of Esters of Substituted 6-Aminohexanoic Acid as Potential Transdermal Penetration Enhancers, in Proceedings of The 12th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2008, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-12-01241
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Synthesis of Esters of Substituted 6-Aminohexanoic Acid as Potential Transdermal Penetration Enhancers

Katerina Brychtova 1
Oldrich Farsa 1
Jozef Csollei 1
1. Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1-3, CZ-612 42 Brno, Czech Republic
Abstract
Skin penetration enhancers are used to allow formulation of transdermal delivery systems for drugs that are otherwise insufficiently skin-permeable. The series of seven esters of substituted 6-aminohexanoic acid as potential transdermal penetration enhancers was formed by multistep synthesis. The general synthetic approach of all newly synthesized compounds is presented. Structure confirmation of all generated compounds was accomplished by 1H NMR, 13C NMR and IR spectroscopy.
Keywords
n/a
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