Events The 12th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 12th International Electronic Conference on Synthetic Organic Chemistry

Published date

23 Nov, 2008

Citation

Georgeta Maria Simu, Sergiu Adrian Chicu, Claudia Crina Toma, Synthesis of Some New Trisazo Dyes and Toxicity Evaluation with the Hydractinia Echinata Test System, in Proceedings of The 12th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2008, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-12-01244

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Synthesis of Some New Trisazo Dyes and Toxicity Evaluation with the Hydractinia Echinata Test System

Georgeta Maria Simu ¹

Sergiu Adrian Chicu ²

Claudia Crina Toma ³

1. Institute of Chemistry Timisoara of the Romanian Academy, B-dul Mihai Viteazul 24, 300223 Timișoara, Romania

2. Siegstrasse 4, 50859 Koln, Germany

3. West University "Vasile Goldis" Arad, Faculty of Pharmacy, Bdul Revolutiei nr. 77, 310130, Arad, Romania

Abstract

The synthesis of three new trisazo dyes containing 4,4'-diaminobenzanilide as middle component is presented. The dyes were analyzed by thin layer chromatography (TLC), electronic spectra (VIS) and their structure was confirmed by mass spectroscopy (FABS). The toxicity of the synthesized dyes was evaluated by biological tests, using the process of metamorphosis in the marine Hydrozoon Hydractinia echinata. The concentration (termed by MRC50) at which the synthesized dyes (and their precursors) antagonize metamorphosis induction was determined. The obtained results indicate that these dyes exhibit toxicity values which are lying in a low average lows scale of toxicity.

Keywords

Direct dyes

4,4'-diaminobenzanilide

toxicity

Hydractinia echinata

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