EventsMOL2NET'22, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 8th ed.
Event submissions
Published
with-doi10.3390/mol2net-08-12450
This submission belongs to the session 05. NICE.XSM-08: North-Ibero-America Congress on Exp. & Simul. Methods, Valencia, Spain-Miami, USA, 2022 of the event MOL2NET'22, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 8th ed.
Published date
23 Mar, 2022
Academic Editor
author-avatarHumbert G. Díaz
Citation
Ester Blanco, Luisa Chocarro, Ana Bocanegra, Hugo Arasanz, Leticia Fernandez, Maider Garnica, Miriam Echaide, Pablo Ramos, Sergio Piñeiro, Karina Ausín, Joaquin Fernández, Enrique Santamaría, David Escors, Grazyna Kochan, Unique protein expression profiles discriminate ex vivo differentiated monocytic MDSCs from TAMs., in Proceedings of MOL2NET'22, Conference on Molecular, Biomed., Comput. & Network Science and Engineering, 8th ed., 1 January–15 January 2023, MDPI: Basel, Switzerland, doi: 10.3390/mol2net-08-12450
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Unique protein expression profiles discriminate ex vivo differentiated monocytic MDSCs from TAMs.

Ester Blanco 1,2
Luisa Chocarro 3
Ana Bocanegra 3
image
Hugo Arasanz 3,4
Leticia Fernandez 3
Maider Garnica 3
Miriam Echaide 3
Pablo Ramos 3
Sergio Piñeiro 3
Karina Ausín 5
Joaquin Fernández 5
image
Enrique Santamaría 5
David Escors 3
Grazyna Kochan 3
1. Oncoimmunology Research Unit, Navarrabiomed-Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), Complejo Hospitalario de Navarra (CHN), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain, Spain
2. Division of Gene Therapy and Regulation of Gene Expression, Cima Universidad de Navarra and Instituto de Investigación Sanitaria de Navarra (IdISNA), Pamplona, Spain
3. Oncoimmunology Research Unit, Navarrabiomed-Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), Complejo Hospitalario de Navarra (CHN), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
4. Medical Oncology Unit, Complejo Hospitalario de Navarra (CHN), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain.
5. Proteomic Research Unit, Navarrabiomed-Fundación Miguel Servet, Universidad Pública de Navarra (UPNA), Complejo Hospitalario de Navarra (CHN), Instituto de Investigación Sanitaria de Navarra (IdiSNA), Pamplona, Spain
Abstract

Detailed knowledge of tumor biology is necessary for tumor reprogramming. Tumor associated macrophages (TAMs) and monocytic myeloid suppressor cells (m-MDSCs) are major tumor-promoting cells within the tumor microenvironment (TME). Differentiation of m-MDSC and TAMs is shaped by tumor microenvironment. Several factors have been shown to drive m-MDSC differentiation into TAMs, indicating that they are two different populations. However, TAMs and m-MDSC closely related functions, phenotypic similarities and differentiation plasticity contributes to the confusion over their ontogeny and differential characteristics. Here, we revealed the key differences between m-MDSC and TAMs, focused on differential pathways by high-throughput proteomics.

Keywords
monocytic myeloid supressor cells (m-MDSCs)
Tumor associated macrophages (TAMs) ,tumor microenvironment (TME).
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