Events The 12th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 12th International Electronic Conference on Synthetic Organic Chemistry

Published date

19 Nov, 2008

Citation

Robert Musiol, Josef Jampilek, Katarina Kralova, Jacek Finster, Dominik Tabak, Halina Niedbala, Jozef Csollei, Jiri Dohnal, Jaroslaw Polanski, Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Their Photosynthesis-inhibiting Activity, in Proceedings of The 12th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2008, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-12-01248

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Ring-substituted 4-Hydroxy-1H-quinolin-2-ones: Preparation and Their Photosynthesis-inhibiting Activity

Robert Musiol ¹

Josef Jampilek ^2,3

Katarina Kralova ⁴

Jacek Finster ¹

Dominik Tabak ¹

Halina Niedbala ¹

Jozef Csollei ³

Jiri Dohnal ^2,3

Jaroslaw Polanski ¹

1. Institute of Chemistry, University of Silesia, Szkolna 9, 40007 Katowice, Poland

2. Zentiva a.s., U kabelovny 130, 102 37 Prague 10, Czech Republic

3. Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic

4. Institute of Chemistry, Faculty of Natural Sciences, Comenius University, Mlynska dolina Ch-2, 84215 Bratislava, Slovakia

Abstract

The series of twelve ring-substituted 4-hydroxy-1H-quinolin-2-one derivatives were prepared. The synthetic procedures of the compounds are presented. All the prepared quinoline derivatives were analyzed using RP-HPLC method for the lipophilicity measurement and their lipophilicity was determined. The prepared compounds were tested for their photosynthesis-inhibiting activity (the inhibition of photosynthetic electron transport in spinach chloroplasts (Spinacia oleracea L.). The relationships between the lipophilicity and the chemical structure of the studied compounds are discussed as well as the structure-activity relationships (SAR) between the chemical structure and the biological activities of the evaluated compounds.

Keywords

Quinolinone derivatives

Lipophilicity

OER inhibition

Spinach chloroplasts

Structure-activity relationships

2’-Hydroxychalcone Analogues: Synthesis and Structure-PGE2 Inhibitory Activity Relationship

Asymmetric methoxyselenenylation of α,b-unsatured carbonyl derivatives