Events The 11th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 11th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2007

Citation

Walid Fathalla, Pavel Pazdera, Synthesis of New 1-Substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene), in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01298

Facebook

Twitter

Synthesis of New 1-Substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene)

Walid Fathalla ¹

Pavel Pazdera ²

1. Department of Mathematical and Physical Sciences, Faculty of Engineering,Suez Canal University, Port-Said, Egypt.

2. Centre for Syntheses at Sustainable Conditions and Their Management, Faculty of Science, Masaryk University, Brno, Czech Republic.

Abstract

Two new 1-substituted-4-(2-phenylquinazolin-4-yl and 4-ylidene) thiosemicarbazides 3 and 5 were formed by multistep domino reaction of imidoyl isothiocyanate derivative 1 with 1,1-di-R hydrazine in acetone solution. Applied hydrazine hydrate under the same reaction condition afforded 4-(2-phenylquinazolin-4(3H)-ylidene)-2-(prop-1-en-2-yl)-1- (propan-2-lidene) thiosemicarbazide (7) via six step three component domino reaction. Compounds 3, 5 and 7 were identified by CHNS elemental analysis, 1 H-NMR,13 C-NMR spectral data and their correlation with ones from known structural motives.

Keywords

quinazoline

thiosemicarbazide

domino reaction

hydrogen bond interaction

Convenient Synthesis of Novel Amino Acid Coupled Benzanilides