EventsThe 11th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-11-01302
This submission belongs to the session a. General Organic Synthesis of the event The 11th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Nov, 2007
Citation
Rosario Torregrosa, Isidro M. Pastor, Miguel Yus, Isoprene-mediated lithiation of chiral N-alkylimidazoles, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01302
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Isoprene-mediated lithiation of chiral N-alkylimidazoles

Rosario Torregrosa 1
Isidro M. Pastor 1
Miguel Yus 1
1. Departamento de Química Orgánica, Facultad de Ciencias and Instituto de Síntesis Orgánica (ISO), Universidad de Alicante, Apdo. 99, 03080 Alicante, Spain
Abstract
The isoprene-mediated lithiation of different chiral N-alkylimidazoles (2a and 2b) and the following reaction with pivalaldehyde leads to the corresponding imidazolylpropanol derivatives 4 and 5 with excellent overall yield, but low de (up to 26%).
Keywords
Different Behaviouof of Disubtituted Aromatic Heterocycles in Polar Diels-Alder Reactions
An Easy Synthesis of 5-Nitro-Thiophenes and 3-Amino-2-Nitro-Thiophenes