EventsThe 11th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-11-01303
This submission belongs to the session a. General Organic Synthesis of the event The 11th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Nov, 2007
Citation
J. C. Rodríguez Domínguez, G. Kirsch, D. Thomae, P. Seck, An Easy Synthesis of 5-Nitro-Thiophenes and 3-Amino-2-Nitro-Thiophenes, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01303
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An Easy Synthesis of 5-Nitro-Thiophenes and 3-Amino-2-Nitro-Thiophenes

J. C. Rodríguez Domínguez 1
G. Kirsch 1
D. Thomae 1
P. Seck 2
1. Laboratoire d’Ingénierie Moléculaire et Biochimie Pharmacologique, Institut Jean Barriol,FR CNRS 2843, Université Paul Verlaine-Metz, 1 Blvd Arago, Metz, 57070, France
2. Laboratoire de Chimie, Faculté des Sciences, de la Technologie et de la Communication, Université du Luxembourg 162a, avenue de la Faïencerie, L-1511 Luxembourg, Grand-Duché de Luxembourg
Abstract
A one-step preparation of substituted 5-nitro thiophenes and 3-amino-2-nitrothiophenes starting from corresponding β-chloroacroleins and β-chloropropenonitriles was developed. Sodium sulfide, bromonitromethane and sodium hydroxide were used as reagents to obtain the expected compounds in good yields with a simple and easy work up procedure.
Keywords
Isoprene-mediated lithiation of chiral N-alkylimidazoles
Knoevenagel Condensation of α-Chloralose Derivative