Events The 11th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 11th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2007

Citation

Jana Raschmanova, Miroslava Martinkova, Jozef Gonda, Stereoselective synthesis of the advanced precursor of (+)-myriocin, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01307

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Stereoselective synthesis of the advanced precursor of (+)-myriocin

Jana Raschmanova ¹

Miroslava Martinkova ¹

Jozef Gonda ¹

1. P J. Safarik University in Kosice, Faculty of Science, Institute of Chemistry, Debartment of Organic Chemistry, Moyzesova 11, Kosice, Slovak Republic

Abstract

A stereoselective approach toward 2-amino-1,3-propanediol 13 is described. This compound represents the key intermediate in the total stereoselective synthesis of (+)-myriocin 1, an inhibitor of serine palmitoyltransferase (SPT). Moreover, synthon 13 can be used for synthesis of mycriocin analogues. 2-amino-1,3-propanediol moiety is necessary for their biological activity.

Keywords

n/a

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