Events8th International Electronic Conference on Medicinal Chemistry
Event submissions
Published
with-doi10.3390/ECMC2022-13146
This submission belongs to the session S8. Pharmaceutical development of the event 8th International Electronic Conference on Medicinal Chemistry
Published date
01 Nov, 2022
Academic Editor
author-avatarMaria Emília Sousa
Citation
Miroslav Sovrlic, Emina Mrkalić, Ratomir Jelić, Nevena Prodanović, Marina Ćendić Serafinović, Interaction between pimethixene and human serum albumin, in Proceedings of 8th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2022, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2022-13146
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Interaction between pimethixene and human serum albumin

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Miroslav Sovrlic 1
Emina Mrkalić 2
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Ratomir Jelić 3
Nevena Prodanović 3
Marina Ćendić Serafinović 4
1. Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Serbia
2. University of Kragujevac, Institute for Information Technologies, Department of Science, Jovana Cvijića bb, Kragujevac 34000, Serbia
3. University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Svetozara Markovića 69, Kragujevac 34000, Serbia
4. University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovića 12, Kragujevac 34000, Serbia
Abstract

Albumin, is the highly abundant protein in the plasma. The main function of protein is delivery various endogenous (fatty acid, vitamins, hormones) and exogenous compounds such as drugs. Further, human serum albumin has a very important role in distribution, free concentration and effectiveness of these compounds.

Pimethixene belongs to the group of antihistamines characterized by sedative and antitussive properties. It has shown remarkable ability to bind to receptors such as serotonin 5-HT2A and 2B, histamine H1 and muscarinic acetylcholine M2. Moreover, oral pimethixene is used to calm dry and irritating coughs in children. However, binding constants of pimetixene for human serum albumin, as the most abundant serum transport protein, have not been determined so far.

Accordingly, in the current study explored the interactions between pimethixene and human serum albumin (HSA) by the spectroscopic measurements (fluorescence spectroscopy and circular dichroism) and molecular docking method.

Keywords
Pimethixene
Human serum albumin
Fluorescence
Circular dichroism
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