EventsThe 11th International Electronic Conference on Synthetic Organic Chemistry
Event submissions
Published
with-doi10.3390/ecsoc-11-01318
This submission belongs to the session a. General Organic Synthesis of the event The 11th International Electronic Conference on Synthetic Organic Chemistry
Published date
30 Nov, 2007
Citation
Media Noori Abdullah, Sonia Arrasate, Esther Lete, Nuria Sotomayor, Stereoselective Synthesis of Thiaerythrinanes via Parham Cyclisation, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01318
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Stereoselective Synthesis of Thiaerythrinanes via Parham Cyclisation

Media Noori Abdullah 1
Sonia Arrasate 1
Esther Lete 1
image
Nuria Sotomayor 1
1. Departamento de Química Orgánica II, Facultad de Ciencia y Tecnología, Universidad del País Vasco / Euskal Herriko Unibertsitatea, Apdo. 644. 48080 Bilbao, Spain
Abstract
Parham cyclisation – intermolecular α-amidoalkylation sequence constitute a route to trans thiazolo[4,3-a]isoquinolinones. These thiazolidindiones, that incorporate allyl groups at C-1 and C-10b, are efficient precursors of thiaerythrinanes by ring-closing methathesis reactions.
Keywords
Lithiation
lithium-halogen exchange
α-amidoalkylation
Parham cyclisation
heterocycles
thiareythrinanes
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