Events8th International Electronic Conference on Medicinal Chemistry
Event submissions
Published
with-doi10.3390/ECMC2022-13203 (registering DOI)
This submission belongs to the session S8. Pharmaceutical development of the event 8th International Electronic Conference on Medicinal Chemistry
Published date
01 Nov, 2022
Academic Editor
author-avatarAlfredo Berzal-Herranz
Citation
Tanja V. Soldatovic, Emina Mrkalić, Biljana Šmit, Ratomir Jelić, Sanja Grgurić-Šipka, Marina Ćendić Serafinović, Interactionts between heterometallic bridged cis-or trans-Pt(II)-Zn(II)complexes and calf thymus DNA, in Proceedings of 8th International Electronic Conference on Medicinal Chemistry, 1 November–30 November 2022, MDPI: Basel, Switzerland, doi: 10.3390/ECMC2022-13203
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Interactionts between heterometallic bridged cis-or trans-Pt(II)-Zn(II)complexes and calf thymus DNA

Emina Mrkalić 1
Biljana Šmit 2
Marina Ćendić Serafinović 3
image
Ratomir Jelić 4
Sanja Grgurić-Šipka 5
image
Tanja V. Soldatovic 6
1. Department of Science, Institute for Information Technologies, University of Kragujevac, Jovana Cvijića bb, Kragujevac 34000, Serbia
2. Institute for Information Technologies, Department of Science, University of Kragujevac, Jovana Cvijića bb, 34000 Kragujevac, Serbia
3. University of Kragujevac, Faculty of Science, Department of Chemistry, Radoja Domanovića 12, 34000 Kragujevac, Serbia
4. University of Kragujevac, Faculty of Medical Sciences, Department of Pharmacy, Svetozara Markovića 69, 34000 Kragujevac, Serbia
5. Department of General and Inorganic Chemistry, University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia
6. Department of Natural-Mathematical Sciences, State University of Novi Pazar, Vuka Karadžića bb, 36300 Novi Pazar, Serbia
Abstract

More recently scientific attention is paid on non-platinum based drug especially on bio-essential metal ions. Design of the heterometallic complexes is possible way to overcome limitation of platinum-based drugs.
The four novel complexes [{cis-PtCl(NH3)(μ-4,4′-bipyridyl)ZnCl(terpy)}](ClO4)2, [{trans-PtCl(NH3)(μ-4,4′-bipyridyl)ZnCl(terpy)}](ClO4)2, [{cis-PtCl(NH3)(μ-pyrazine)ZnCl(terpy)}](ClO4)2 and [{trans-PtCl(NH3)(μ-pyrazine)ZnCl(terpy)}](ClO4)2 (where terpy = 2,2′:6′,2′′-terpyridine) were synthesized and characterized. The binding of the heterometallic bridged cis-or trans-Pt(II)-Zn(II) complexes to calf thymus DNA (CT-DNA) was studied using UV absorption and fluorescence emission spectroscopy. The results indicate that the complexes bind strongly to DNA (Kb, in the order of 104 M−1) through groove binding, hydrogen bonds, and hydrophobic or electrostatic interaction. According to Stern–Volmer quenching constant (KSV) and binding constant (K), the [{cis-PtCl(NH3)(μ-4,4′-bipyridyl)ZnCl(terpy)}](ClO4)2 complex interacts with CT-DNA-EB more strongly than the rest of the studied complexes.

Keywords
zinc(II)
platinum(II)
DNA interactions
heterometalic complexes
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