Events The 11th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session a. General Organic Synthesis of the event The 11th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2007

Citation

Dang Van Tinh, Wolfgang Stadlbauer, Regioselective and Sequential Mono- and Diamination of 5,7-Dichloro-pyrido[2,3-d]pyrimidine-2,4-diones, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01331

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Regioselective and Sequential Mono- and Diamination of 5,7-Dichloro-pyrido[2,3-d]pyrimidine-2,4-diones

Dang Van Tinh ^1,2

Wolfgang Stadlbauer ³

1. School of Pharmacy, University of Medicine and Pharmacy at Hochiminh City 41 Dinh Tien Hoang Str., Dist. 1, Ho Chi Minh City, Vietnam

2. Institut für Chemie, Organic Synthesis Group, Karl-Franzens-University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria

3. Institut für Chemie, Organic Synthesis Group, Karl-Franzens-University of Graz Heinrichstrasse 28, A-8010 Graz (Austria)

Abstract

5-Amino- and 5,7-diamino-pyrido[2,3-d]pyrimidine-2,4-diones were prepared easily from the corresponding 5,7-dichloro-pyrido[2,3-d]pyrimidine-2,4-diones with aliphatic and aromatic amines. The 7-monoazides, obtained by azidation of the chlorides, were converted to iminophosphoranes by reaction with triphenylphosphane via Staudinger reaction. Hydrolysis produced in one step 7-amino-pyrido[2,3-d]pyrimidine-2,4-diones.

Keywords

n/a

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