Events The 11th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session b. Solid Phase Chemistry and Combinatorial Synthesis of the event The 11th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2007

Citation

PierFrancesco Biagini, Abel Crespo, Alberto Coelho, Eddy Sotelo, Synthetic Applications of Polystyrene-Supported 1,1,3,3-Tetramethylguanidine, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01335

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Synthetic Applications of Polystyrene-Supported 1,1,3,3-Tetramethylguanidine

PierFrancesco Biagini ¹

Abel Crespo ¹

Alberto Coelho ¹

Eddy Sotelo ^1,2

1. Unidad de Química Combinatoria, Instituto de Farmacia Industrial (IFI), Spain

2. Departamento de Química Orgánica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, 15782, Spain

Abstract

Several applications of polystyrene-supported 1,1,3,3-tetramethylguanidine (PS-TMG) in synthetic organic chemistry have been explored. This study evidenced the effectiveness and versatility of this new member of the supported guanidine superbases as an attractive candidate to replace the bases usually employed in organic synthesis during the implementation of environmentally friendly preparative processes.

Keywords

Supported reagents

TMG

base

2-Substituted 4-, 5- and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-Substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as Potent Platelet Aggregation Inhibitors: Design, Synthesis and SAR Studies

Synthesis of (HET)ARYLAMIDOGUANIDINES and their Anticoagulant Activity Evaluation