Events The 11th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 11th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2007

Citation

Wai-Keung Chui, Anna A. Dolzhenko, Boris Ya. Syropyatov, Olga V. Sherbakova, Dmitry V. Kalinin, Svetlana A. Ustinova, Anna A. Krasnova, Anton V. Dolzhenko, Synthesis of (HET)ARYLAMIDOGUANIDINES and their Anticoagulant Activity Evaluation, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01336

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Synthesis of (HET)ARYLAMIDOGUANIDINES and their Anticoagulant Activity Evaluation

Wai-Keung Chui ¹

Anna A. Dolzhenko ¹

Boris Ya. Syropyatov ²

Olga V. Sherbakova ²

Dmitry V. Kalinin ²

Svetlana A. Ustinova ²

Anna A. Krasnova ²

Anton V. Dolzhenko ¹

1. Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore

2. Department of Physiology, Perm State Pharmaceutical Academy, Perm, Russian Federation

Abstract

(Het)arylamidoguanidines were synthesized from corresponding hydrazides and S-methyl isothiourea. They were screened in vitro for anticoagulant activity using whole canine blood. The most active compounds, namely 4-methylbenzamidoguanidine and nicotinamidoguanidine were also tested on platelet free plasma. No effect was observed for these compounds on the clotting time of platelet free plasma. Therefore, platelets were suspected as a possible target for the anticoagulant activity of the (het)arylamidoguanidines.

Keywords

n/a

Synthetic Applications of Polystyrene-Supported 1,1,3,3-Tetramethylguanidine

Reductive Biotransformation of Ethyl Acetoacetate: A Comparative Studies using Free and Immobilized Whole Yeast Cells