Events The 11th International Electronic Conference on Synthetic Organic Chemistry

Event submissions

Published

This submission belongs to the session c. Bioorganic Chemistry and Natural Products of the event The 11th International Electronic Conference on Synthetic Organic Chemistry

Published date

30 Nov, 2007

Citation

Maria J. G. Fernandes, M. Sameiro T. Gonçalves, Susana P. G. Costa, Photocleavage Studies of γ-aminobutyric acid (GABA) Conjugates, in Proceedings of The 11th International Electronic Conference on Synthetic Organic Chemistry, 1 November–30 November 2007, MDPI: Basel, Switzerland, doi: 10.3390/ecsoc-11-01338

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Photocleavage Studies of γ-aminobutyric acid (GABA) Conjugates

Maria J. G. Fernandes ¹

M. Sameiro T. Gonçalves ¹

Susana P. G. Costa ¹

1. Centro de Química, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal

Abstract

Polycyclic aromatic labels such as naphthalene and pyrene were coupled to the C- terminus of N-benzyloxycarbonyl protected -aminobutyric acid (GABA). The photophysical properties of the corresponding fluorescent conjugates were evaluated, as well as their behaviour towards photocleavage by irradiation in MeOH/HEPES buffer solution (80:20), in a photochemical reactor at different wavelengths (254, 300, 350 and 419 nm), followed by HPLC/UV monitoring.

Keywords

Naphthalene

Pyrene

-Aminobutyric acid (GABA)

Photocleavable protecting groups

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