Structure, properties and biological activity of chitosan salts with L- and D-aspartic acid

A comprehensive study of the structure, properties and biological functionality of salt chitosan complexes with L- and D-aspartic acid (AspA) was carried out. It has been established that these polymer salts differ in spatial organization, chirooptic characteristics, surface charge, and macrocoil size. In experiments in vitro on a wide range of biological objects (unicellular algae, planktonic crustaceans, aerobic bacterial microorganisms, cell cultures, and test plants) it was found that the chitosan salt with D-AspA exhibited the best biological activity. The results obtained confirm our hypothesis that the biological homochiral hierarchy principles are most consistent with chitosan (D-aminoglucan) derivatives with the D-antipode of the acid.